Pinealon is a neuroprotective tripeptide derived from pineal gland tissue that supports cognitive function, reduces neuronal oxidative damage, and is studied as an anti-aging compound for the brain and nervous system.
This peptide profile is for research and educational purposes only. Not intended for human use or self-administration.
Overview
Pinealon (Glu-Asp-Arg) is a short bioregulatory tripeptide developed by the St. Petersburg Institute of Bioregulation and Gerontology, following the same systematic tissue-derived peptide methodology as Cartalax and Cortagen. Derived from pineal gland tissue, it is studied for its neuroprotective, cognitive-enhancing, and anti-aging effects on the central nervous system. The pineal gland's regulatory peptides are of particular interest because the gland coordinates circadian rhythm, neuroendocrine function, and the brain's antioxidant defense. Pinealon is proposed to restore pineal-derived gene expression signals that decline with age-related pineal involution.
Mechanism of Action
Pinealon interacts with chromatin in neurons and pineal cells, modulating the accessibility of gene promoters involved in antioxidant defense, neuronal survival, and circadian regulation. It appears to activate genes encoding superoxide dismutase (SOD) and other antioxidant enzymes in neuronal tissue, reducing reactive oxygen species damage. It also supports the expression of melatonin synthesis pathway enzymes in the pineal gland. Research suggests Pinealon can reduce ischemia-induced neuronal damage, support mitochondrial function in neurons, and slow the accumulation of age-related oxidative DNA damage in brain tissue. Like other Khavinson peptides, it is thought to act as an epigenetic reset signal for tissue-specific gene expression.
Key Research
Pinealon was developed and studied at the St. Petersburg Institute of Bioregulation and Gerontology. Animal studies documented neuroprotective effects in models of cerebral ischemia, showing reduced neuronal death and improved functional recovery when given pre- or post-ischemia. Aging studies in rodents showed Pinealon-treated animals maintained cognitive function on maze tests and had lower levels of oxidative damage markers in brain tissue compared to controls. Combined protocols with Epithalon showed synergistic anti-aging effects on both pineal and neuroendocrine function. Published research is predominantly from the Khavinson group with limited independent Western replication.
100–200 mcg subcutaneously daily, in 10-day cycles
Half-Life
~30–60 minutes
Pinealon is used at 100–200 mcg subcutaneously daily for 10-day cycles, repeated 2–3 times per year. Some protocols use oral or sublingual delivery. It pairs well with Epithalon for a comprehensive pineal and telomere support protocol, and with Semax for neuroprotective stacking. It is typically well tolerated and can be used by older adults as part of anti-aging maintenance without significant side effects.
Cognitive Anti-Aging Stack: Pinealon 100 mcg SC daily for 10 days + Epithalon 10 mg SC daily for 10 days (concurrent pulse cycles, run twice per year). Add Semax 200 mcg intranasally daily during the same period for BDNF support. Neurological Recovery Support: Pinealon 150 mcg SC daily + BPC-157 250 mcg SC daily for 10 days as a neuroprotective support adjunct.
Reported Side Effects
Side effects summarized from animal studies and researcher community observations. Educational purposes only — not medical advice.
Pinealon has an excellent safety profile based on available research with no documented significant adverse events. At the low microgram doses used in research, systemic effects are minimal. Mild injection site redness may occur. No dependency, no receptor desensitization, and no withdrawal effects have been documented. Suitable for elderly individuals. Theoretical consideration: individuals with seizure disorders should consult a professional before use, as the CNS-active nature of the peptide warrants precaution in that context.
Storage & Handling
Store lyophilized Pinealon at 2–8°C, protected from light. Stable for up to 12 months. Reconstitute with bacteriostatic or sterile water. As a tripeptide, it is relatively stable in solution — use reconstituted solution within 14–21 days when refrigerated. Store away from heat and repeated temperature cycling.
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