Perimenopause

Perimenopause Symptom Relief Stack

Perimenopause brings converging hormonal, neurological, and sleep disruptions — this stack addresses each without introducing exogenous hormones. Kisspeptin-10 works with the body's existing HPG axis to moderate the hormonal fluctuations responsible for hot flashes, mood instability, and libido changes; Selank reduces the norepinephrine-driven neurological component of hot flashes and the anxiety amplification of hormonal transitions; and DSIP directly targets the non-restorative sleep that is among the most debilitating aspects of perimenopause. Full effects typically take 3–4 weeks to build as Kisspeptin-10 restores HPG axis pulsatility.

Beginner 10 week cycle 3 peptides Save

Protocol & Dosing

HPG Axis Support (twice weekly):

Kisspeptin-10: 75 mcg subcutaneously twice weekly (morning, fasted)

Evening Neurological Support:

Selank: 250 mcg intranasally or subcutaneously 1 hour before bed
DSIP: 200 mcg subcutaneously 30–45 minutes before bed

As-Needed (acute hot flash or anxiety episodes):

Selank: 250 mcg intranasally as needed, up to 3x daily

Cycle: 10 weeks on / 4 weeks off

Notes: Track symptom response weekly — hot flash frequency, sleep quality, mood stability, and cognitive clarity are the key outcome markers. This protocol may take 3–4 weeks to show full effect as Kisspeptin-10 builds HPG axis pulsatility. Consult with a healthcare provider familiar with peptide protocols before combining with prescribed HRT.

Calculate Doses for This Stack

Use the Peptide Oracle calculator to get exact BAC water ratios and draw amounts for every peptide in this protocol.

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